DAR No 5: Guanfacine. Intuniv® for the treatment of attention deficit hyperactivity disorder (ADHD)

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And old friend with much to demonstrate

Guanfacine is a centrally-acting antihypertensive and a non-stimulant selective alpha-2A adrenergic receptor agonist.
It has not been proven to be superior or equal to any of the other drugs available for ADHD.
No data are available on its longterm safety profile of neurocognitive effects.
Its most common side effects include: sleepiness, headache, fatigue, abdominal pain, sedation, and weight gain.
Worrying cardiovascular safety profile: hypotension, bradycardia, and fainting.
The cost per patient is higher than that of atomoxetine.

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