• No comparative studies have been performed versus the antidepressants of choice.
• There is no evidence that it has similar or higher effectiveness than other antidepressants.
• Indirect studies suggest that vortioxetine is less effective than duloxetine and venlafaxine.
• The safety profile -except for nausea- is similar to that of SSRIs and SNRIs, although long-term studies have not been performed.
• Not all studies have proven that it is more effective than placebo.
• There is more evidence on the effectiveness of SSRI antidepressants, and they have a better risk/ benefit balance. Therefore, SSRIs should be the treatment of choice

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