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DAR No 2: Asenapine (Sycrest®) for maniac episodes
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Another drug with no advantages and complicated to administer
- Asenapine is an antipsychotic drug is indicated for the treatment of moderate to severe manic episodes associated with bipolar I disorder in adults.
- Statistically significant improvements have been observed in comparison to placebo in the YMRS scale score, although the benefits are of scarce magnitude and uncertain clinical relevance.
- The drugs safety profile is similar to other atypical antipsychotics. The most characteristic adverse effects include hypersensitivity reactions and oral hypoesthesia.
- The drug is made exclusively for sublingual use as it is ineffective if ingested. It should be taken 10 minutes before any food or water is taken and 10 minutes after any other drug. Its particular route of administration is an important inconvenience.
