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DAR No 2. Grass pollen allergen Phleum pratense (Grazax®) in allergic rhinitis and conjunctivitis induced by grass pollen
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A long and expensive preventive treatment with very modest results
- Pollen extract from Phleum pratense (Timothy grass) has been introduced in the market for the treatment of allergic rhinitis and conjunctivitis caused by a grass pollen when clinically relevant symptoms are present and specific tests confirm the origin of the allergy.
- Four clinical trials studying this agent have been published. In three of them, the agent proved slightly more effective than placebo in the improvement of symptoms, and in one trial the efficacy of the agent was not higher than placebo.
- A significant percentage of patients was affected by adverse effects, oral pruritus the most frequent reaction reported (46-56%).
- There are no comparative trials with subcutaneous immunotherapy.
