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DAR No 11. Liraglutide (Victoza®) in type 2 diabetes
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Similar to exenatide
- The efficacy of liraglutide is similar to glimepiride and slightly higher than glargine and exenatide, although the clinical relevante is scarce.
- It produces weight loss comparable to exenatide, higher at the start of treatment and in patients with a high body mass index.
- Withdrawals due to adverse effects and the safety profile is similar to exenatide. The incidence of hypoglycemia is low, and increases when combined with suphonylureas.
- There is uncertainty with regard to the cardiovascular safety profile, its action on thyroid gland, pancreatitis and immunogenicity. There is no information available on long-term safety of the drug.
- There is no information on the efficacy with regard to diabetes complications and mortality.
